Extreme potentiation of DNA Repair #33
Description
While enhancement of tumor suppressors or suppression of oncogenes are the most potent ways to increase lifespan, potentiating DNA Repair itself can be surprisingly potent.
The second largest mammal (a whale) on earth live 200 year old and it's most specific mutation isn't p53 over expression as in elephants but a protein implicated in DNA repair and cell cycle (also increase thioredoxin 1)
https://pubmed.ncbi.nlm.nih.gov/41162698/
Which might be more targetable than p53
It has been proven to work in human cells